Kuongorora kweBurkitt Lymphoma
Burkitt lymphoma ndiyo yakanyanya hutsinye subtype ye lymphoma, uye inofungidzirwa kuti ndiyo inokurumidza kukura - kana kuti yakanyanya hutsinye mhando yegomarara.
Nokuti inotanga uye inopararira nokukurumidza, inoda kurapwa ne-intensive chemoimmunotherapy nokukurumidza mushure mekuongororwa. Nekudaro, nekuti chemotherapy inoshanda zvakanyanya pamaseru ari kukurumidza kukurumidza, inobata zvakanyanya pakuparadza masero eBurkitt Lymphoma.
Vanhu vazhinji vane Burkitt Lymphoma vanogona kurapwa.
Kunzwisisa B-cell lymphocytes
Burkitt Lymphoma igomarara reB-cell lymphocytes, saka kuti unzwisise Burkitt Lymphoma unofanirwa kuziva zvishoma nezveB-Cell lymphocytes yako.
B-Cell lymphocytes:
- Imhando yemasero machena eropa.
- Rwisa utachiona nezvirwere kuti uchengetedze hutano.
- Rangarira utachiona hwawaiva nahwo munguva yakapfuura, saka kana ukawana utachiona humwe chetehwo zvakare, immune system yemuviri wako inogona kurwisa zvakanyanya uye nekukurumidza.
- Inogadzirwa mumwongo wako (iyo spongy chikamu pakati pemapfupa ako), asi kazhinji inogara muspleen yako uye lymph nodes yako. Vamwe vanogara mu thymus neropa rako zvakare.
- Inogona kufamba kuburikidza ne lymphatic system yako, kune chero chikamu chemuviri wako kurwisa hutachiona kana chirwere.
Burkitt Lymphoma inokura apo mamwe eB-masero ako anova kenza. Dzinokura zvisingadzoreki, hadzina kujairika, uye hadzife padzinofanira kufa.
Paunenge uine Burkitt Lymphoma, yako kenza B-cell lymphocytes:
- Kurai muwande nekukurumidza.
- Hazvishande zvinobudirira kurwisa hutachiona uye zvirwere.
- Tarisa uye uzvibate zvakasiyana kune ako ane hutano B-masero.
- Inogona kukonzera lymphoma kukura uye kukura munzvimbo dzakawanda dzemuviri wako.
Subtypes yeBurkitt Lymphoma
Kune akasiyana subtypes e-lymphoma. Dzvanya pamisoro pazasi kuti udzidze nezve akasiyana subtypes.
Endemic Burkitt Lymphoma, iyo inowanzoonekwa nevanhu vane mamiriro eAfrica, uye ndiyo lymphoma inowanikwa zvikuru muvana veAfrica. Inowanzoonekwawo kune vanhu vane marariya kana Epstein-Barr virus (EBV).
Endemic Burkitt Lymphoma inowanzotanga mushaya yako, kana pane mamwe mapfupa echiso chako, asi inogona zvakare kutanga mudumbu mako (mudumbu).
Sporadic Burkitt Lymphoma inogona kuitika munzvimbo ipi neipi yepasi uye semalymphoma mazhinji anofungidzirwa kuti anowanzoitika muvanhu vakambobatwa nehutachiona hweEpstein-Barr. Inowanzotanga mudumbu mako, saka inogona kuva yakajairika kumarwadzo kana kusagadzikana mudumbu rako.
Sporadic Burkitt Lymphoma inogona kupararira kune yako yepakati tsinga system, kusanganisira uropi hwako uye musana, thyroid gland, tonsils uye mapfupa kumeso kwako.
Immunodeficiency-associated Burkitt Lymphoma inowanzoonekwa kune vanhu vane simba rekudzivirira zvirwere, uye inowanikwa kune vanhu vane utachiona hweHIV (HIV) kana kuti vakawana immunodeficiency syndrome (AIDS).
Nekudaro, iyi subtype inogona zvakare kukura kana iwe ukatora mishonga inokuita iwe immune system senge inotorwa mushure mekuisirwa nhengo kana uine autoimmune chirwere.
Zvakawanda sei Burkitt Lymphoma?
Burkitt lymphoma inobata vanhu vezera ripi zvaro, kusanganisira vana nevakuru. Ndirwo rudzi rwakawanda rwe lymphoma muvana vane makore ari pakati pemashanu negumi uye runoumba 5% yemalymphoma evacheche - zvinoreva kuti vana vatatu pagumi voga voga vane lymphoma vachave neBurkitt Lymphoma.
Iyo ishoma muvanhu vakuru vane 1 kana 2 chete mukuru kubva pazana rega rega (100-1%) vane lymphoma ine Burkitt Lymphoma. Muvanhu vakuru, inowanzoitika kune avo vane makore ari pakati pe2-30 makore.
Zviratidzo zveLymphoma
Zvimwe zviratidzo zveBurkitt lymphoma zvakafanana nezviratidzo zveimwe lymphomas, uye zvimwe zvingave zvakabatana neiyo lymphoma iri kukura.
Nzvimbo dzakajairika Burkitt Lymphoma dzinogona kuwanikwa dzinosanganisira:
- lymph nodes mumutsipa wako, armpit uye groin
- dumbu rako uye ura hwako
- yako yepakati tsinga system (CNS) - uropi uye musana
- bone marrow
- spleen, chiropa uye dzimwe nhengo dzemuviri wako
- rushaya rwako kana mamwe mapfupa kumeso kwako.
Nodal uye yakawedzera nodal Burkitt Lymphoma
Burkitt Lymphoma inogona kutanga mumalymph nodes ako kana kunze kwemalymph nodes ako. Kana yatanga mumalymph nodes yako inonzi "nodal". Kana yatanga kunze kwemalymph nodes ako - semunhengo dzako kana mwongo inonzi "extra nodal".
Chiratidzo chinonyanyozivikanwa chenodal Burkitt Lymphoma kuzvimba lymph nodes zvinogona kuitika chero chikamu chemuviri wako. Iwo anowanzo kunzwika mumutsipa wako, muhapwa kana mugodhi, nekuti aya malymph nodes ari padyo neganda rako.
Asi isu tinewo lymph nodes muchipfuva chedu, dumbu, maoko, makumbo uye musoro. Nekuti Burkitt Lymphoma inokura nekupararira nekukurumidza unogona kuona ma lymph nodes munzvimbo dzakawanda dzemuviri wako achizvimba.
Zvimwe zviratidzo zvekuzvimba lymph nodes kana extranodal lymphoma
Zvichienderana nenhengo dzemuviri wako dzine lymph nodes dzakazvimba unogona kuona zviratidzo zvakasiyana. Malymph nodes akawanda akazvimba ane chekuita nelymphoma haarwadze, asi anogona kurwadza kana akaisa kumanikidza kune dzimwe nhengo, tsinga kana kuti akakura zvakanyanya.
Pamusoro pemalymph nodes, isu zvakare tine lymphoid tishu munzvimbo dzakasiyana dzemiviri yedu senge muromo wedu, dumbu, ura, mapapu. Lymphoid tishu inzvimbo dzemasero edziviriro anogara munzvimbo dzemiviri yedu kuti titarise uye kurwisa hutachiona. Burkitt Lymphoma inogonawo kutanga kana kupararira kune chero yenzvimbo idzi zvakare.
Zviratidzo zvinogona kusanganisira zvinotevera.
Nzvimbo yakakanganiswa | zviratidzo |
Chifuva kana mutsipa | Kupfupika kwemhepo Shanduko kuzwi rako Chikosoro chinoramba chiripo Marwadzo, kumanikidzwa kana kusagadzikana muchipfuva kana mutsipa Shanduko kune rhythm yemoyo kana kudzvanywa kuri pamoyo wako |
Central nerve system (Brain, spinal cord uye nzvimbo kuseri kwemaziso ako) | Kuvhiringidzika kana kushanduka kwendangariro Chizutu Shanduko pakuona kwako Kushaya simba, kurira kana kupisa Kuoma kufamba Kunetsa kuenda kuchimbuzi Kugumburwa (kukwana) Unhu hunochinja |
Ura - (Muromo, dumbu & ura) | Nausea nekurutsa kana kusarutsa Dharare kana kuvimbiswa Dumbu rakazvimba (ungatoita kunge une nhumbu) Ropa paunoenda kuchimbuzi Kunzwa kuguta kunyangwe usina kudya, kana kudya zvishoma Zvakaoma kumedza. |
Bone Marrow | Shanduko kuhuwandu hweropa rako hwakanaka hunosanganisira:
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Nhengo dze lymphatic system yako - Spleen uye thymus
Spleen inhengo inosefa ropa rako richirichengetedza. Iyo zvakare inhengo ye lymphatic system yako iyo yako B-cell lymphocytes inogara uye inoburitsa masoja ekudzivirira chirwere kurwisa hutachiona. Iri kuruboshwe rwedumbu rako repamusoro pasi pemapapu ako uye pedyo nedumbu rako (tummy).
Kana spleen yako yanyanya kukura, inogona kuisa simba padumbu rako uye kuita kuti unzwe wakaguta, kunyange usina kudya zvakanyanya. Unogonawo kuwana:
- Kuderera kweropa kuverengera.
- Kunyanya kuneta.
- Kuonda.
- Jaundice (yellowing yeganda rako nemaziso).
- Marwadzo mudumbu rako kana kunzwa kwe "bloating".
Your thymus zvakare chikamu che lymphatic system yako. Inhengo yakaita shavishavi inogara kuseri kwebhonzo rezamu kumberi kwechipfuva chako. Mamwe masero eB anoraramawo uye anopfuura nepakati pe thymus yako. Kana lymphoma iri mu thymus yako unogona kuva nebundu muchipfuva chako taht inogona kuvhara dzimwe nhengo muchipfuva chako. Sympoms inogona kufanana neiyo yakanyorwa patafura iri pamusoro.
Chiropa
- Jaundice.
- Marwadzo kana kusagadzikana zvinogona kupenya kusvika pabendekete rako rekuruboshwe.
- Kurasikirwa nechido uye kuonda.
- Kuzvimba kwedumbu rako nekuda kwekuvakwa kwemvura (ascites).
- Kubuda ropa zvisina kujairika.
B-zviratidzo
B-zviratidzo zvinogona kuitika kana lymphoma iri kushingaira kukura. Inogona kuratidza kuti lymphoma iri kushandisa simba rako rekuchengetedza kana kuti iri kugadzira makemikari anokanganisa nzira iyo muviri wako unodzora kupisa kwako. Nguva dzose taura B-zviratidzo kuna chiremba wako.
Kuongororwa uye Staging yeBurkitt Lymphoma
Kana chiremba wako achifunga kuti iwe unogona kunge uine lymphoma, ivo vachada kuronga akati wandei akakosha bvunzo. Iyi miedzo inodiwa kusimbisa kana kubvisa lymphoma sechikonzero chezviratidzo zvako.
Kuti uongorore Burkitt Lymphoma iwe uchada biopsy. Biopsy inzira yekubvisa chikamu, kana yese ye lymph node yakakanganisika uye/ kana sampuli yemwongo. Biopsy inozoongororwa nemasayendisiti murabhoritari kuti vaone kana paine shanduko dzinobatsira chiremba kuongorora chirwere cheBurkitt.
Paunenge uine biopsy, unogona kuve neanotindivadza emunharaunda kana general. Izvi zvinoenderana nerudzi rwebiopsy uye kuti chikamu chipi chemuviri wako chinotorwa kubva. Kune mhando dzakasiyana dzebiopsies uye ungangoda anopfuura imwe chete kuti uwane yakanakisa sampuli.
Kuyera ropa
Kuongororwa ropa kunotorwa paunenge uchiedza kuongorora lymphoma yako, asiwo mukati mekurapa kwako kuti uone kuti nhengo dzako dziri kushanda nemazvo uye dzinogona kurarama nekurapa kwedu.
Core kana yakanaka tsono biopsy
Core kana yakanaka tsono biopsies inotorwa kubvisa sampuli yekuzvimba lymph node kana bundu kutarisa zviratidzo zve lymphoma.
Chiremba wako anowanzo shandisa anesthetic yemunharaunda kuita chiveve nzvimbo kuitira kuti usanzwe kurwadziwa panguva yekuitwa, asi iwe unenge wakamuka panguva iyi biopsy. Vanozoisa tsono mukati me lymph node yakazvimba kana bundu uye vobvisa sampuli yetishu.
Kana lymph node yako yakazvimba kana bundu rakadzika mukati memuviri wako biopsy inogona kuitwa nerubatsiro rweultrasound kana nyanzvi x-ray (imaging) kutungamira.
Iwe unogona kunge uine general anesthetic yeizvi (zvinoita kuti urare kwechinguva chidiki). Iwe unogona zvakare kuve nematehwe mashoma mushure.
Core tsono biopsy inotora sampuli yakakura kupfuura yakanaka tsono biopsy.
Excisional node biopsy
Excisional node biopsies inoitwa kana lymph node yako yakazvimba kana bundu rakadzika zvakanyanya mumuviri wako kuti risvike nepakati kana yakanaka tsono biopsy. Iwe uchave uine general anesthetic iyo inokurarisa kwechinguva chidiki kuti ugare wakanyarara, uye usanzwe kurwadziwa.
Munguva iyi, chiremba anovhiya anobvisa lymph node yose kana bundu uye anotumira kune pathology yekuongororwa.
Iwe uchange uine ronda diki rine zvinyoro zvishoma, uye kupfeka pamusoro.
Misono inowanzogara kwemazuva 7-10, asi chiremba wako kana mukoti achakupa rairo yekuti ungachengeta sei kupfeka, uye nguva yekudzokera kuti unosonwa.
Burkitt Lymphoma Kuongororwa
Kana chiremba wako angowana mhinduro kubva kwauri kuongororwa ropa uye biopsies vanozokwanisa kukuudza kana uine Burkitt Lymphoma uye vanogona zvakare kukuudza kuti ndeupi subtype yeBurkitt yaunayo. Vachazoda kuita mimwe miedzo kusvika padanho uye giredhi lymphoma yako.
Kuita uye Kukwirisa Burkitt Lymphoma
Kana uchinge waonekwa kuti une Burkitt Lymphoma, chiremba wako achava nemimwe mibvunzo nezve lymphoma yako. Izvi zvinosanganisira:
- Ndeipi nhanho lymphoma yako?
- Ndeupi subtype yeBurkitt yaunayo?
Dzvanya pamisoro iri pazasi kuti udzidze zvakawanda nezve staging uye giredhi.
Staging inoreva kuwanda kwemuviri wako kukanganiswa ne lymphoma yako - kana, kuti yakapararira zvakadii kubva kwayakatanga.
B-masero anogona kufamba kune chero chikamu chemuviri wako. Izvi zvinoreva kuti masero e-lymphoma (kenza B-masero), anogonawo kuenda kune chero chikamu chemuviri wako. Iwe unozofanirwa kuita bvunzo dzakawanda kuti uwane ruzivo urwu. Miyedzo iyi inodaidzwa kuti staging tests uye kana wawana zvabuda, unozoona kuti une danho rekutanga (I), danho rechipiri (II), danho rechitatu (III) kana danho rechina (IV) Burkitt Lymphoma. Nekudaro, nekuti Burkitt's ine hukasha kazhinji inenge yatova nhanho yepamusoro (nhanho 3 kana 4) kana waonekwa,
Nhanho yako ye lymphoma ichaenderana ne:
- Ingani nzvimbo dzemuviri wako dzine lymphoma
- Apo lymphoma inosanganisira kana iri pamusoro, pasi kana kumativi ose maviri e diaphragm yako (musuru mukuru, wakaita dome pasi pembabvu inoparadzanisa chipfuva kubva mudumbu rako)
- Kunyangwe iyo lymphoma yakapararira kumapfupa ako emapfupa kana dzimwe nhengo dzakadai sechiropa, mapapu, ganda kana pfupa.
Matanho I uye II anonzi 'kutanga kana nhanho diki' (inosanganisira nzvimbo shoma yemuviri wako).
Matanho III neIV anonzi 'advanced stage' (yakawanda).
Stage 1 | imwe lymph node nzvimbo inobatwa, kungave pamusoro kana pasi pe diaphragm * |
Stage 2 | nzvimbo mbiri kana kupfuura dze lymph node dzinobatwa kune rimwe divi re diaphragm * |
Stage 3 | kana lymph node imwe kumusoro uye imwe lymph node nzvimbo iri pasi pe diaphragm* inobatwa |
Stage 4 | lymphoma iri mumalymph nodes akawanda uye yakapararira kune dzimwe nhengo dzemuviri (semumapfupa, mapapu, chiropa) |
Kuwedzera ruzivo rwekuita
Chiremba wako anogonawo kutaura nezvedanho rako achishandisa tsamba, senge A, B, E, X kana S. Mavara aya anopa mamwe mashoko pamusoro pezviratidzo zvaunazvo kana kuti muviri wako uri kukanganiswa sei ne lymphoma. Ruzivo rwese urwu runobatsira chiremba wako kuwana chirongwa chekurapa chakanakira iwe.
tsamba | zvichireva | kukosha |
A kana B |
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E & X |
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S |
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(Spleen yako inhengo iri mu lymphatic system yako inosefa nekuchenesa ropa rako, uye inzvimbo yako B-cells kuzorora uye kugadzira masoja ekudzivirira chirwere) |
Miedzo yekutamba
Kuti uzive kuti ndeipi nhanho yauinayo, unogona kukumbirwa kuti uite mamwe eanotevera nhanho bvunzo:
Computed tomography (CT) scan
Aya ma scans anotora mifananidzo yemukati mechipfuva chako, dumbu kana pelvis. Vanopa mifananidzo yakadzama inopa ruzivo rwakawanda kupfuura yakajairwa X-ray.
Positron emission tomography (PET) scan
Iyi scan inotora mifananidzo yemukati memuviri wako wese. Iwe uchapihwa uye tsono nemumwe mushonga masero ane kenza - senge lymphoma masero anotora. Mushonga unobatsira PET scan kuona kuti lymphoma iripi uye saizi uye chimiro nekusimbisa nzvimbo dzine lymphoma masero. Nzvimbo idzi dzimwe nguva dzinonzi "zvinopisa".
Lumbar kubaya
A lumbar puncture inzira yakaitwa yekutarisa kana uine chero lymphoma mune yako yepakati tsinga system (CNS), iyo inosanganisira uropi hwako, musana uye nzvimbo yakapoteredza maziso ako. Iwe unozofanira kutaura zvakadzikama panguva yekuitwa, kuitira kuti vacheche nevana vanogona kuve neanotindivadza kuti varare kwechinguva chidiki ichiitwa. Vazhinji vanhu vakuru vanongoda mushonga wekutindivadza wepanzvimbo kuitira kuti maitiro aite chiveve nzvimbo.
Chiremba wako achaisa tsono kumusana kwako, uye oburitsa mvura shoma inonzi “cerebral spinal fluid” (CSF) kubva pakatenderedza musana wako. CSF imvura inoita zvishoma sechinhu chinokatyamadza kuCNS yako. Inotakurawo mapuroteni akasiyana uye hutachiona hunorwisa masero edziviriro senge lymphocytes kuchengetedza uropi hwako uye musana. CSF inogonawo kubatsira kubvisa chero mvura yakawedzerwa yaungave uine muuropi hwako kana kutenderedza musana wako kudzivirira kuzvimba munzvimbo idzodzo.
Sampuli yeCSF inozotumirwa kune pathology uye kuongororwa chero zviratidzo zve lymphoma.
Bone marora bhiopsy
- Bone marrow aspirate (BMA): bvunzo iyi inotora shoma shoma yemvura inowanikwa munzvimbo yemwongo.
- Bone marrow aspirate trephine (BMAT): bvunzo iyi inotora diki diki yemwongo tishu.
Iwo masampuli anobva atumirwa kune pathology uko anotariswa zviratidzo zve lymphoma.
Maitirwo emuwongo biopsies anogona kusiyana zvichienderana nekuti uri kurapwa kupi, asi kazhinji anozosanganisira mushonga wekutindivadza wepanzvimbo kuti uite chiveve nzvimbo.
Mune zvimwe zvipatara, unogona kupihwa light sedation iyo inokubatsira kuti uzorore uye inogona kukumisa kuyeuka maitiro. Zvisinei vanhu vazhinji havadi izvi uye vanogona kunge vaine "muridzo yegirinhi" yekuyamwa. Iyi muridzo yegirinhi ine mushonga wekuuraya marwadzo mairi (unonzi Penthrox kana methoxyflurane), waunoshandisa sezvinodiwa mukati memaitiro ese.
Ita shuwa kuti unobvunza chiremba wako izvo zviripo kuti uwedzere kugadzikana panguva yekuita, uye taura navo pamusoro pezvaunofunga kuti ichava sarudzo yakanakira iwe.
Ruzivo rwakawanda pamusoro pemapfupa biopsies anogona kuwanikwa pane yedu peji rewebhu pano.
Burkitt Lymphoma ndiyo yakanyanya hutsinye lymphoma subtype uye yakanyanya hutsinye cancer. Nokudaro, inogara ichionekwa seyepamusoro-grade lymphoma.
Giredhi inoreva kukurumidza kuwanda kwemasero, kuti anotaridzika sei uye maitiro aanoita.
Masero e-high grade lymphoma anowedzera nokukurumidza, anotaridzika zvakasiyana kubva kune yako B-cell lymphocyte uye haakwanisi kushanda nenzira iyo lymphocytes inofanira kushanda nayo.
Ngozi yakaderera uye Yakanyanya njodzi Burkitt Lymphoma
Chiremba wako anogonawo kutaura nezveBurkitt yako senjodzi yakanyanya kana njodzi yakaderera. Urwu ndirwo rumwe ruzivo rwavanoshandisa kuona marapirwo akakunakira iwe. Ngozi yako ichatemwa zvichibva pane zvinotevera:
- Pasinei nokuti une lymphoma muhutano hwako hwehutano (CNS).
- Kana bvunzo dzeropa rako dzichiratidza yakakwira lactate dehydrogenase (LDH).
- Kana iwe uine chero genetic rearrangements kana shanduko.
Cytogenetic kuyedza
Cytogenetic miedzo inoitwa kuti utarise kusiyanisa kwemajini kungave kubatanidzwa muchirwere chako. Kuti uwane rumwe ruzivo nezve izvi ndapota ona chikamu chedu pakunzwisisa yako lymphoma genetics zvakare pasi peji ino. Miedzo inoshandiswa kutarisa chero genetic mutations inonzi cytogenetic tests. Iyi bvunzo inotarisa kuona kana iwe uine chero shanduko mumakromosomes uye majini.
Kazhinji tine 23 mapeya emachromosome, uye anoverengwa zvichienderana nekukura kwawo. Kana uine Burkitt Lymphoma, machromosomes ako anogona kutaridzika zvishoma.
Chii chinonzi majini uye chromosomes
Sero rimwe nerimwe rinoumba muviri wedu rine nucleus, uye mukati memukati mune mapeya 23 emakromosomes. Chromosome imwe neimwe inogadzirwa netambo refu dzeDNA (deoxyribonucleic acid) ine majini edu. Majini edu anopa kodhi inodiwa kugadzira maseru nemapuroteni ese ari mumuviri wedu, uye anovaudza maitiro ekutarisa kana kuita.
Kana pane shanduko (kusiyana) mumakromosomes aya kana majini, mapuroteni ako nemasero haashande nemazvo.
Lymphocytes inogona kuva masero e-lymphoma nekuda kwekuchinja kwemajini (kunonzi kushanduka kana kusiyana) mukati memasero. Yako lymphoma biopsy inogona kutariswa nenyanzvi yepathologist kuona kana uine chero gene mutations.
Kutamiswa muBurkitt Lymphoma
MuBurkitt Lymphoma iwe uchave nemusiyano mumajeni ako anonzi translocation. Izvi zvinoitika kana chikamu chidiki chemakromosomes maviri chichichinjana nzvimbo. Jeni rinogara richikanganisa Burkitt Lymphoma rinosanganisira iyo MYC gene pa8th chromosome uye translocation inoitika nejini pa14th chromosome. Unozoona yakanyorwa kuti t(8:14).
Kurapa kweBurkitt Lymphoma
Kana zvese zvawawana kubva kubiopsy, cytogenetic kuyedzwa uye mastaging scans apera, chiremba anozoongorora izvi kuti asarudze kurapwa kwakanakisisa kwauri. Kune dzimwe nzvimbo dzegomarara, chiremba achasanganawo nechikwata chenyanzvi kuti vakurukure nzira yekurapa yakanakisa. Izvi zvinonzi a Multidisciplinary team (MDT) musangano.
Chiremba wako achafunga zvakawanda nezveBurkitt Lymphoma yako, asi iwe uchafanirwa kutanga kurapwa ne chemo-immunotherapy munguva pfupi mushure mekuongororwa. Pasina kurapwa Burkitt Lymphoma inouraya, zvisinei nekurapwa kune mukana wakanaka kwazvo wekupora.
Chemo-immunotherapy zvinoreva kuva nemishonga inonzi chemotherapy uye monoclonal antibody. Monoclonal antibodies inowanzonzi immunotherapy nekuti inobatsira immune system kurwisa cancer. Chemotherapy inoshanda nekurwisa zvakananga masero ari kukurumidza kukura.
Zvimwe zvinhu izvo chiremba wako achafunga nezvazvo paunenge uchironga kurapwa kwako zvinosanganisira yako:
- imwe nhanho ye lymphoma, genetic shanduko uye zviratidzo
- zera, nhoroondo yezvekurapa yapfuura uye hutano hwese
- hutano hwazvino hwemuviri nepfungwa uye zvinodiwa nemurwere
- chero zviratidzo zvauri kuwana.
Mimwe bvunzo
Mimwe miedzo inogona kurairwa usati watanga kurapwa kuti uve nechokwadi chekuti moyo wako, mapapu neitsvo zvinokwanisa kurarama nekurapwa. Izvi zvinogona kusanganisira ECG (electrocardiogram), lung function test kana 24-awa yekuunganidza weti.
Chiremba wako kana mukoti wegomarara anogona kukutsanangurira hurongwa hwekurapa kwako uye zvinogona kuitika kwauri, uye varipo kupindura chero mubvunzo waungave uine. Zvakakosha kuti ubvunze chiremba wako uye/kana mukoti wegomarara mibvunzo nezve chero chausinganzwisise.
Unogonawo kufonera kana kutumira email kune Lymphoma Australia Mukoti Helpline nemibvunzo yako uye tinogona kukubatsira kuti uwane ruzivo rwakakwana.
Lymphoma care nurse hotline:
Foni: 1800 953 081
Email: nurse@lymphoma.org.au
Mibvunzo yekubvunza chiremba wako usati watanga kurapwa
Zvinogona kunetsa kuziva kuti ndeipi mibvunzo yekubvunza paunenge uchitanga kurapwa. Kana iwe usingazive, zvausingazive, ungaziva sei zvekubvunza?
Kuva neruzivo rwakakodzera kunogona kukubatsira kuti unzwe uine chivimbo uye kuziva zvekutarisira. Inogonawo kukubatsira kuronga pachine nguva pane zvaungade.
Tinoisa pamwe chete rondedzero yemibvunzo yaungawana inobatsira. Zvechokwadi, mamiriro ezvinhu emunhu wose akasiyana, saka mibvunzo iyi haitauri zvose, asi inopa mavambo akanaka.
Dzvanya pane iyi link iripazasi kuti utore inodhinda PDF yemibvunzo yachiremba wako.
Kuchengetwa Kwesimba
Kurapa kweBurkitt Lymphoma kunogona kukanganisa kubereka kwako (kukwanisa kuita vana). Izvi zvinogona kuitika kune vese vakuru nevana, varume nevakadzi. Kana iwe (kana mwana wako) uchida vana gare gare muhupenyu, taura nachiremba wako nezve kana kubereka kwako kunogona kuchengetedzwa kune gare gare.
Common Treatment Protocols kune Vakuru vane Burkitt Lymphoma
Kurapa kwako kunowanzo shanda zvakanyanya kupikisa lymphoma yako, asi kunogona kukanganisa masero ako akanaka. Saka unoda nguva yekuti masero ako akanaka adzoke. Masero ane hutano anodzokorora nekukurumidza kupfuura masero e-lymphoma nekuti ane zvakawanda zvakarongeka.
Maitiro ekurapa akajairika aunogona kupihwa anosanganisira:
DA-R-EPOCH (dose yakagadziriswa rituximab, etoposide, prednisolone, vincristine, cyclophosphamide, doxorubicin)
R-CODOX-M (rituximab, cyclophosphamide, vincristine, doxorubicin, methotrexate)
- R-CODOX-M inopinhaniswa ne R-IVAC (rituximab, ifosfamide, etoposide, cytarabine)
GMALL 2002 (varwere vanopfuura makore 55)
GMALL 2002 (varwere vari pasi pemakore 55)
Hyper CVAD chikamu A
- Hyper CVAD chikamu A chinotsinhaniswa nacho Hyper CVAD Chikamu B
Yakajairwa Kurapa Protocols yeVana vane Burkitt Lymphoma
- R-COPADM: rituximab, cyclophosphamide, vincristine, methotrexate, cytarabine, Prednisolone, doxorubicin, etoposide.
- SVIRA LMB 89: cyclophosphamide, vincristine, methotrexate, doxorubicin), cytarabine, etoposide
Mimwe misiyano yechemotherapy protocol inoshandiswa muvana Burkitt lymphoma inosanganisira:
- CHOP: cyclophosphamide, daunorubicin, vincristine uye prednisolone
- COPAD: cyclophosphamide, cytarabine, doxorubicin, vincristine, etoposide, Prednisolone.
- COPADM: cyclophosphamide, methotrexate, cytarabine, doxorubicin, vincristine, etoposide
Yakadzoka zvakare kana Refractory Burkitt Lymphoma
Mune zvimwe zviitiko, lymphoma yako inogona kusapindura kumutsara wekutanga wekurapa waunayo. Kana izvi zvikaitika, lymphoma yako inonzi refractory.
Dzimwe nguva, unogona kuwana mhinduro yakanaka kubva pakurapa kwako, asi lymphoma inogona kudzoka zvakare (kudzoka) mushure menguva yakati.
Kune zvese zviri zviviri refractory uye kudzokazve Burkitt Lymphoma iwe uchapihwa kumwe kurapwa.
Kurapa mumutsara wechipiri kana wechitatu kunogona kusanganisira:
- kunyanya immuno-chemotherapy
- tsinga cell kutapurirana
- CAR T-cell kurapa
Kuti uwane rumwe ruzivo nezve marapirwo uye zvinhu zvekufunga nezvazvo ona peji redu rekurapa.
Clinical trials
Zvinokurudzirwa kuti chero nguva yaunoda kutanga mishonga mitsva unobvunza chiremba wako nezvemakiriniki ekuedza iwe unogona kukodzera.
Miedzo yemakiriniki yakakosha kuwana mishonga mitsva, kana misanganiswa yemishonga yekuvandudza kurapwa kweBurkitt Lymphoma. mune ramangwana.
Vanogona zvakare kukupa mukana wekuyedza mushonga mutsva, musanganiswa wemishonga kana kumwe marapirwo ausingakwanise kuwana kunze kwekuedzwa. Kana iwe uchida kutora chikamu muchirongwa chekiriniki, bvunza chiremba wako kuti ndeapi miedzo yekiriniki yaunokodzera.
Kune akawanda marapirwo uye misanganiswa yekurapa mitsva iri kuongororwa mumakiriniki ekuedzwa pasi rese kune varwere vane vese vachangobva kuongororwa uye vadzoka zvakare Burkitt Lymphoma.
Prognosis yeBurkitt Lymphoma - uye chii chinoitika kana kurapwa kwapera
Prognosis ishoko rinoshandiswa kutsanangura nzira ingangove yechirwere chako, kuti chichapindura sei kurapwa uye kuti uchaita sei panguva uye mushure mekurapwa.
Pane zvakawanda zvinokonzeresa kufungidzira kwako uye hazvigoneke kupa chirevo chakazara nezve prognosis. Zvisinei, Burkitt Lymphoma inowanzopindura zvakanaka pakurapwa uye varwere vazhinji vane gomarara iri vanogona kurapwa - zvichireva kuti mushure mekurapwa, hapana chiratidzo cheBurkitt Lymphoma mumuviri wako. Zvisinei, kune boka duku revanhu ringave risingadavirewo pakurapwa.
Zvinhu zvinogona kukanganisa prognosis
Zvimwe zvinhu zvinogona kukanganisa prognosis yako zvinosanganisira:
- Iwe zera uye hutano hwese panguva yekuongororwa.
- Mapinduriro aunoita pakurapwa.
- Ko kana paine genetic mutations iwe unayo.
- Iyo subtype yeBurkitt Lymphoma yaunayo.
Kana iwe uchida kuziva zvakawanda nezve fungidziro yako, ndapota taura nenyanzvi yako yehematologist kana oncologist. Vachakwanisa kutsanangura njodzi yako uye fungidziro kwauri.
Kupona - Kurarama, uye mushure megomarara
Mararamiro ane hutano, kana mamwe mararamiro akanaka anochinja mushure mekurapwa anogona kubatsira zvikuru kupora kwako. Pane zvinhu zvakawanda zvaunogona kuita kukubatsira kurarama zvakanaka mushure meBurkitt.
Vanhu vazhinji vanoona kuti mushure mekuongororwa kenza, kana kurapwa, kuti zvinangwa zvavo uye zvavanokoshesa muhupenyu zvinoshanduka. Kusvika pakuziva kuti 'itsva yako yakajairika' chii kunogona kutora nguva uye kushungurudza. Zvinotarisirwa nemhuri yako neshamwari zvinogona kunge zvakasiyana nezvako. Iwe unogona kunzwa uri wega, wakaneta kana chero nhamba yemanzwiro akasiyana anogona kuchinja zuva rega rega.
Zvinangwa zvikuru mushure mekurapa lymphoma yako ndiko kudzokera kuhupenyu uye:
- shingairira sezvinobvira mubasa rako, mhuri, nemamwe mabasa ehupenyu
- kuderedza migumisiro yechirwere uye zviratidzo zvegomarara uye kurapwa kwayo
- tsvaga uye gadzirisa chero mhedzisiro yekunonoka
- batsira kuti urambe wakasununguka sezvinobvira
- vandudza hupenyu hwako uye chengetedza hutano hwakanaka hwepfungwa
Mhando dzakasiyana dzekugadzirisa kenza dzinogona kukurudzirwa kwauri. Izvi zvinogona kureva chero yemhando dzakasiyana zvemasevhisi akadai se:
- kurapa kwepanyama, kugadzirisa marwadzo
- kudya uye kuronga maekisesaizi
- manzwiro, basa uye mazano emari.
pfupiso
- Burkitt Lymphoma ndiyo mhando yegomarara rinotyisa raunogona kuwana - asi izvi zvinoreva kuti rinowanzopindura zvakanaka pakurapwa.
- Vanhu vazhinji vane Burkitt Lymphoma vanogona kurapwa.
- Burkitt Lymphoma inoitika apo B-cell lymphocytes yako ikava kenza uye inogona kukanganisa vana nevakuru.
- Iwe unozoda kurapwa ne chemo-immunotherapy nekukurumidza mushure mekunge waonekwa.
- Mune zvimwe zviitiko, lymphoma yako inogona kusapindura kurapwa, kana inogona kudzokera shure mushure mekurapa uye iwe unoda mamwe kurapwa kana izvi zvikaitika.
- Bvunza chiremba wako nezve miedzo yekiriniki yaungakodzera.
