Kune mishonga yakawanda inogona kupihwa semumuromo (nemuromo) kurapa lymphoma uye chronic lymphocytic leukemia.
Mhedziso yekurapa kwemuromo mu lymphoma (& CLL)
Lymphoma uye chronic lymphocytic lymphoma (CLL) kurapwa inogona kuva musanganiswa wemishonga inorwisa kenza. Vanowanzo kupihwa mutsinga (intravenously) uye kazhinji inosanganisira musanganiswa wemishonga inosanganisira antibody therapy uye chemotherapy (immunochemotherapy).
Izvi zvinowanzobatanidza kurapwa kuchipatara kana kune imwe nzvimbo yegomarara. Nekudaro, pane zvakawanda zvakakura mugomarara rekurapa lymphoma uye CLL iyo inogona kutorwa nemuromo mune piritsi fomu. Idzi dzinozivikanwa sekurapa nemuromo.
Chii chinonzi kurapwa kwepamuromo?
Oral lymphoma therapies inogona kuva chemotherapy mishonga, inotarirwa marapirwo, uye immunotherapies. Inogona kutorwa nemuromo sehwendefa, capsule, kana semvura. Mushonga unopinzwa muropa wotakurwa semishonga inopinzwa mutsinga.
Kurapa nemuromo kunogona kungoshanda semasarudzo ekuisa mutsinga uye ivo vanewo mamwe maitiro akasiyana. Pane zvinhu zvakawanda zvine chekuita ne subtype ye lymphoma uye mamiriro ekurapa emurwere anofanirwa kuve akaenzana kusarudza kurapa kwakanakisa kweiyo lymphoma. Nokudaro, sarudzo inonyanya kuitwa mukukurukurirana nenyanzvi.
Kurapa nemuromo kunoshandiswa riini?
Mishonga yakawanda yemumuromo inoshandiswa kurapa lymphoma neCLL ndeye immunotherapy agents kana marapirwo anonangwa. Kurapa kwakanangwa kunonangana nema enzymes anodiwa kuti lymphoma ikure nepo mishonga yechemotherapy inonangidzirwa pamasero anopatsanura nekukurumidza angave ari lymphoma kana mamwe masero akajairwa mukati memuviri wemunhu.
Sezvo mishonga yechemotherapy isingasiyanise pakati pemaseru e-lymphoma uye akajairwa masero ane hutano anokuvadza nekusaziva maseru ane hutano anotungamira kumhedzisiro senge kuderedzwa kweropa, kurasikirwa nebvudzi, maronda emukanwa, kuda kurutsa, kurutsa uye manyoka nepo kurapwa kwakanangwa kazhinji kunokanganisa mashoma akajairwa maseru anokonzeresa. mune mashoma emhando idzi dzemigumisiro yakakomba.
Kutanga kurapwa nemuromo
Varwere vasati vatanga kurapwa kumba:
- Chiremba achanyora kurapwa
- Mushori wemishonga achapa mushonga kumurwere
- Nguva yakatarwa icharongwa kuti ikurukure kurapwa uye migumisiro inogona kuitika
Mukoti kana wemishonga anotsanangura zvakadzama matorerwo emishonga uye izvi zvinosanganisira dosi uye kuti inoda kutorwa kangani. Mirayiridzo ichapiwa pamusoro pekubata nekuchengetedzwa kwemishonga. Zvose zvinokonzerwa nemishonga zvichakurukurwa, uye mashoko akanyorwa achapiwa kumurwere.
Zvinhu zvekuziva nezvekutora mishonga yemuromo
Kurapa kwegomarara remuromo kunogona kuve sarudzo iri nyore kune varwere sezvavanogona kutorwa kumba, zvisinei pane zvishoma zvinhu zvekufunga nezvazvo:
- Varwere vane basa rekuona kuti vatora mishonga yavo, saka panogona kunge paine njodzi yakawedzera yekukanganisa kwemishonga sekukanganwa kunwa mushonga.
pane mamwe mazuva kana kutora dose isiriyo iyo inogona kukanganisa kushanda kwemushonga. - Izvo zvakakosha kuti varwere vatore mishonga yese sekurairwa kuti kuwedzere kushanda kwekurapa uye kuderedza chero mhedzisiro. Sezvo kuchengeta mishonga yese kuchigona kunetsa, taura kuchikwata chenyanzvi nezve nzira yekuramba uchitevera. Zvishandiso zvakasiyana-siyana zvinogona kubatsira kusanganisira kurekodha mishonga mudhiyari kana kugadzira zviyeuchidzo zvepamhepo mumaapps kana pa smartphone
- Varwere vanogona kunzwa kushomeka kuchikwata chavo chenyanzvi sezvavaizoita dai vaiwana mishonga inoiswa mutsinga nekuti vanoshanya kuchipatara kana nzvimbo yegomarara. Nekudaro, kunwa mishonga yekunwa kumba kunogona kubatsira kune varwere vanofanirwa kufamba daro refu kuenda kuchipatara chavo maererano nenguva nemari inoshandiswa pakufamba.
- Maside effects anogonawo kusaonekwa kana kusamhan'arwa kuchikwata chenyanzvi uye patents anogona kunge asina chokwadi magadzirisiro emhedzisiro kumba. Nokudaro, zvakakosha kudzidzisa varwere nevachengeti vavo pamusoro pezvinhu zvakakosha izvi. Mazhinji emigumisiro yemishonga yemuromo inogona kuderedzwa nerubatsiro rwerutsigiro saka varwere vanofanira kunyatsocherechedza zvose zvinokonzerwa nemishonga yavo uye vazivise kune chikwata chenyanzvi pazvinoitika, saka vanowana rubatsiro rwakanakisisa.
Kuchengetedza paunenge uchitora mushonga wemuromo kumba
Kutanga kurapwa kumba:
- Kurapa nemuromo hakufaniri kumbobatwa nemaoko. Inogona kukonzera kushatirwa
- Geza maoko zvakanaka nesipo nemvura mushure mekubata mishonga
- Pfeka magirovhosi paunenge uchichinja hembe kana machira akasvibiswa nemarutsi kana manyoka
- Chengetedza mapiritsi sekurairwa nemushonga wemishonga
- Chengetedza mapiritsi zvakachengeteka kure nevana nemhuka dzinovaraidza
- Tora kurapwa nemuromo sezvakarayirwa
- Takura runyoro rwemishonga yose yazvino
- Ronga zvekufamba, kuzadzazve, uye kupera kwevhiki
- Kana uchinzwa kusanzwa zvakanaka chero nguva taura neboka rako rehutano
- Zivisa chero vamwe vapi vehutano nezvemishonga yemuromo inorwisa gomarara
- Dzorera mishonga yese isina kushandiswa ku pharmacy kuti uraswe zvakachengeteka
Mhando dzeoral therapy
TGA yakatenderwa (iyo TGA ndiyo Therapeutic Goods Authority muAustralia) marapirwo egomarara remuromo mishonga inotadzisa kukura uye kukurudzira kufa kwemasero elymphoma. Mimwe mishonga yekudzivirira zvirwere inosimudzira immune system yemurwere kuziva masero elymphoma uye kukurudzira kuparadzwa kwemasero aya. Kune akati wandei makirasi emishonga iyi akanyorwa pazasi:
Oral chemotherapy inoshandiswa mu lymphoma
muiti |
kirasi |
How akunoita |
Subtypes |
Mhedzisiro inowanzoitika |
| Cyclophosphamide | Chemotherapy: Alkylating mumiriri | Kemikari inoshandura DNA kukonzera kufa kwemasero ari kukura | CLL HL NHL | Ropa rakaderera Kurwara Nausea & kurutsa Kufirwa kwechido |
| Etoposide | Chemotherapy: Topoisomerase II inhibitor | Inopindira ne topoisomerase enzymes inodzora kubata kwechimiro cheDNA chinodiwa pakudzokorora. | CTCL NHL | Nausea & kurutsa Kufirwa kwechido Diarrhea Kuneta |
| Chlorambucil | Chemotherapy: Alkylating mumiriri | Kemikari inoshandura DNA kukonzera kufa kwemasero ari kukura | CLL FL HL NHL | Ropa rakaderera Kurwara Nausea & kurutsa Diarrhea |
Mamwe marapirwo emuromo anoshandiswa mu lymphoma
muiti |
kirasi |
How akunoita |
Subtypes |
Mhedzisiro inowanzoitika |
| Ibrutinib | BTK Inhibitor | Inodzivisa enzyme inobatanidzwa muB cell receptor siginecha inodiwa kuti lymphoma cell kupona uye kukura | CLL MCLs | Matambudziko emoyo mutinhimira Matambudziko ekubvisa High blood pressure · Zvirwere |
| Acalabrutinib | BTK inhibitor | Inodzivisa enzyme inobatanidzwa muB cell receptor siginecha inodiwa kuti lymphoma cell kupona uye kukura | CLL MCLs | kurwadziwa nemusoro Diarrhea Kuwedzera kwehuwandu |
| Zanubrutinib | BTK inhibitor | Inodzivisa enzyme inobatanidzwa muB cell receptor siginecha inodiwa kuti lymphoma cell kupona uye kukura | CLL MCLs WM | Ropa rakaderera Mapundu Diarrhea |
| Idelalisib | P13K Inhibitor | Inodzivisa enzyme inobatanidzwa muB cell receptor siginecha inodiwa kuti lymphoma cell kupona uye kukura | CLL FL | Manyoka Matambudziko echiropa Matambudziko emapapu Utachiona |
| Venetoclax | BCL2 Inhibitor | Inotarisira mapuroteni anozivikanwa kudzivirira lymphoma masero kubva pakufa | CLL | Nausea Manyoka Matambudziko ekubuda ropa Utachiona |
| Lenalidomide | Immunomodulatory agent | Mamichina chaiwo haazivikanwe. Kufunga kugadzirisa immune system. | Inoshandiswa mune dzimwe NHL | Mapundu paganda Nausea Diarrhea |
| Vorinostat | HDAC Inhibitor | Inhibits HDAC enzymes inodiwa pakutaura kwemajini muDNA kudzivirira lymphoma cell kukura uye kupatsanura. | CTCL | Kufirwa kwechido Dry mouth Kurasika kwebvudzi Utachiona |
| Panobinostat | HDAC Inhibitor | Inhibits HDAC enzymes inodiwa pakutaura kwemajini muDNA kudzivirira lymphoma cell kukura uye kupatsanura. | HL CTCL | High magnesium mazinga Yakakwira bilirubin mwero Nausea zvirwere |
| Bexarotene | Retinoids | Sarudzo inosunga uye inomisa retinoid receptors zvichikonzera kutaura kwemajini anodzora sero kukura uye kudzokorora | CTCL | Kushanda kweganda Nausea Low thyroid hormones mazinga zvirwere |
