Kune marudzi maviri makuru ekutapurirana, autologous uye allogeneic stem cell transplants.
Dr Nada Hamad, chiremba weHematologist & mapfupa ekutamisa mapfupa
Chipatara cheSt Vincent's, Sydney
Chii chinonzi stem cell?
- Maso matsvuku eropa (kusanganisira lymphocytes - ndiwo masero ayo kana aita kenza anokonzera lymphoma)
- Masero matsvuku eropa (aya ane basa rekutakura okisijeni kutenderedza muviri)
- Platelets (masero anobatsira ropa kuvhara kana kudzivirira kugwamba)
Chii chinonzi stem cell transplant?
A stem cell transplant inzira inogona kushandiswa kurapa lymphoma. Inogona kushandiswa kurapa varwere vane lymphoma iri mukuregererwa asi pane mukana mukuru we lymphoma ichadzoka zvakare (inodzoka). Inogonawo kushandiswa kurapa varwere vane lymphoma yakadzoka zvakare (dzoka).
A stem cell transplant inzira yakaoma uye inopindira inoitika mumatanho. Varwere vari kuita stem cell transplant vanotanga kugadzirwa nechemotherapy chete kana musanganiswa neradiotherapy. Mushonga wechemotherapy unoshandiswa mu stem cell transplants unopihwa pamadosi akakwira kupfuura zvakajairwa. Sarudzo yechemotherapy yakapihwa padanho iri zvinoenderana nerudzi uye chinangwa chekuisirwa. Kune nzvimbo nhatu dzekuti stem masero ekutapurirana anogona kuunganidzwa kubva:
Bone marrow cells: stem masero anounganidzwa zvakananga kubva mumwongo uye anonzi a 'bone marrow transplant' (BMT).
Peripheral stem masero: stem masero anounganidzwa kubva muropa uye izvi zvinonzi a 'peripheral blood stem cell transplant' (PBSCT). Iyi ndiyo inonyanya kuwanika ye stem masero anoshandiswa pakusimwa.
Cord blood: stem masero anounganidzwa kubva mumbilical cord mushure mekuberekwa kwechecheche. Izvi zvinonzi a 'cord blood transplant', uko izvi zvisinganyanyi kuwanda pane peripheral kana bone marrow transplants.
Mhando dze stem cell transplants
Kune marudzi maviri makuru ekutapurirana, autologous uye allogeneic stem cell transplants.
Autologous stem cell transplants: rudzi urwu rwekuchinjisa runoshandisa masero emurwere ega, anounganidzwa nekuchengetwa. Iwe unozove uine yakakwira dosi yechemotherapy uye uchitevera izvi stem masero ako anozodzoserwa kwauri.
Allogeneic stem cell transplant: rudzi urwu rwekuchinjisa runoshandisa akapihwa stem masero. Anopa anogona kunge aine hukama (nhengo yemhuri) kana mupi asina hukama. Vanachiremba vako vanoedza nekutsvaga mupi ane masero anoenderana nemurwere. Izvi zvinoderedza njodzi yemuviri kuramba iyo donor stem masero. Murwere achange aine madosi akawanda echemotherapy uye dzimwe nguva radiotherapy. Kutevera izvi masero akapihwa stem achadzoserwa kumurwere.
Kuti uwane rumwe ruzivo rwakadzama pane imwe neimwe yemhando idzi dzekuchinjisa, ona autologous kuisirwa or allogeneic transplant mapeji.
Zviratidzo zvekuisirwa stem cell
Dr Amit Khot, chiremba weHematologist & chiremba wekuisira mwongo
Peter MacCallum Cancer Center uye Royal Melbourne Hospital
Vazhinji varwere vanoonekwa kuti vane lymphoma vanoita NOT vanoda stem cell transplant. Ose ari maviri autologous uye allogeneic stem cell transplantation anongoshandiswa mune mamwe mamiriro. Zviratidzo zvikuru zve stem cell transplant zvinosanganisira:
- Kana murwere ane lymphoma ane refractory lymphoma (lymphoma isingateereri kurapwa) kana dzokazve lymphoma (lymphoma inoramba ichidzoka mushure mekurapa).
- Zviratidzo zve autologous transplant (masero ega) zvakasiyanawo nezviratidzo zve allogeneic (donor cells) transplant.
- Varwere veLymphoma vanowanzo gamuchira autologous transplant pane kuisirwa allogeneic. An autologous transplant ine njodzi shoma uye zvishoma matambudziko uye kazhinji inobudirira mukurapa lymphoma.
Zviratidzo zve autologous (zvake masero) stem cell transplant zvinosanganisira:
- Kana lymphoma ikadzoka (inodzoka)
- Kana iyo lymphoma inopesana (haipinduri kurapwa)
- Vamwe varwere vanoonekwa kuti vane lymphoma inozivikanwa kuva nemukana wakakura wekudzokazve, kana kana lymphoma iri kunyanya danho repamusoro, rinozotariswa seautologous transplant sechikamu chekutanga chirongwa chekurapa.
Zviratidzo zve allogeneic (donor) stem cell transplant zvinosanganisira:
- Kana iyo lymphoma ikadzoka mushure me autologous (yake masero) stem cell transplant
- Kana lymphoma iri refractory
- Sechikamu chechipiri- kana chechitatu-mutsara kurapwa kwe relapsed lymphoma/CLL
The transplantation process
Dr Amit Khot, chiremba weHematologist & chiremba wekuisira mwongo
Peter MacCallum Cancer Center uye Royal Melbourne Hospital
Pane nhanho shanu dzakakura dzinobatanidzwa mukuchinjisa:
- Kugadzirira
- Kuunganidzwa kwe stem masero
- Conditioning
- Kudzorera stem cell
- Engraftment
Iyo nzira yemhando yega yega yekuisirwa inogona kunge yakasiyana zvakanyanya. Kuti uwane rumwe ruzivo:
Dr Amit Khot, chiremba weHematologist & chiremba wekuisira mwongo
Peter MacCallum Cancer Center uye Royal Melbourne Hospital
