Zvinhu zvekukura ndezvemakemikari (akaitwa nemunhu) anokurudzira masero kuti aparadzanise uye akure. Kune akawanda akasiyana ekukura zvinhu anokanganisa marudzi akasiyana emaseru. Muviri wako unoita zvinhu zvekukura zvakasununguka.
Ndezvipi zvinhu zvinokura?
Granulocyte-colony stimulating factor (G-CSF) inogadzirwa mumuviri nehurongwa hwekudzivirira zvirwere uye inokurudzira kuumbwa kweimwe rudzi rwemasero machena eropa, neutrophil. Neutrophils inotora chikamu mukuita kwekuzvimba uye ine basa rekuona nekuparadza mabhakitiriya anokuvadza, mavhairasi, uye mamwe fungi.
Zvimwe zvinhu zvinokura zvinogonawo kugadzirwa murabhoritari. Izvi zvinogona kushandiswa kukurudzira kugadzirwa kwemasero matsva muvarwere vanoada.
Mhando dzakasiyana dzeG-CSF dzinogona kushandiswa:
- Lenograstim (Granocyte®)
- Filgrastim (Neupogen®)
- Lipegfilgrastim (Lonquex®)
- Pegylated filgrastim (Neulasta®)
Ndiani anoda kukura zvinhu?
Kuti kurapwa neG-CSF kuchidiwa kana kusadiwa zvinoenderana ne:
- Rudzi uye nhanho ye lymphoma
- The chemotherapy
- Kunyangwe neutropenic sepsis yakaitika munguva yakapfuura
- Kurapa kwakapfuura
- zera
- General utano
Zviratidzo zveG-CSF
Pane zvikonzero zvakati kuti nei varwere ve lymphoma vangangoda kugamuchira G-CSF. Zvikonzero zvinogona kusanganisira:
- Kudzivirira neutropenic sepsis. Chemotherapy ye lymphoma ine chinangwa chekuuraya masero e-lymphoma asi mamwe masero ane hutano anogonawo kukanganiswa. Izvi zvinosanganisira masero machena anonzi neutrophils. Kurapa neG-CSF kunobatsira neutrophil kuverenga kupora nekukurumidza. Inogona kushandiswa kuderedza njodzi ye neutropenic sepsis. Vanogonawo kudzivirira kunonoka kana kuderedzwa kwedosi mumakemotherapy cycles.
- Kurapa neutropenic sepsis. Neutropenic sepsis inguva apo murwere ane mwero wakaderera weutrophils anowana hutachiona hwaasingakwanise kurwisa uye kuita septic. Kana vakasawana kurapwa kwekukurumidzira, zvinogona kutyisidzira hupenyu.
- Kuwedzera kugadzirwa kwe stem cell uye kuunganidza kusati kwaitwa pfupa rekudyara. Zvinhu zvinokura zvinokurudzira bhonzo kuti riite stem masero muhuwandu. Vanovakurudzirawo kuti vabve mumwongo vopinda muropa, umo vanogona kuunganidzwa nyore nyore.
Inopiwa sei?
- G-CSF inowanzopihwa sejekiseni pasi peganda (subcutaneously)
- Ijekiseni rekutanga rinopihwa muchipatara kuti ritarise chero maitiro
- Mukoti anogona kuratidza murwere kana munhu anotsigira majekiseni eG-CSF kumba.
- Mukoti wenharaunda anogona kushanya zuva rega rega kuzobaya jekiseni, kana kuti rinogona kubaiwa kunaChiremba wezvirwere zvese.
- Kazhinji vanouya mune imwe-kushandisa, pre-yakazadzwa sirinji
- Majekiseni eG-CSF anofanira kuchengetwa mufiriji.
- Bvisa jekiseni mufiriji maminitsi makumi matatu isati yadiwa. Inonyanya kugadzikana kana iri kamuri tembiricha.
- Varwere vanofanirwa kuyera tembiricha yavo mazuva ese uye kungwarira zvimwe zviratidzo zvehutachiona.
Maside effects emajekiseni eG-CSF
Huwandu hwemasero machena eropa mumuviri huchaongororwa nguva nenguva nekuongororwa ropa apo varwere vanenge vachibaiwa majekiseni eG-CSF.
Zvimwe zvakajairika side-effects
- Nausea
- Kudzora
- Pfupa kurwadziwa
- chimhepo
- Kuneta
- Kuora bvudzi
- Diarrhea kana kusvira
- Chizutu
- Mapundu
- Headaches
Cherechedza: vamwe varwere vanogona kutambura nekurwadziwa kwakanyanya kwepfupa, kunyanya muzasi. Izvi zvinoitika sezvo majekiseni eG-CSF achikonzera kukurumidza kuwedzera kweutrophils uye kuzvimba kupindura mumwongo. Mwongo wepfupa unonyanya kuwanikwa munzvimbo yepelvic (hudyu / yezasi). Izvi zvinoitika kana masero machena eropa achidzoka. Mudiki murwere anowedzera kurwadziwa, sezvo mwongo wemapfupa uchiri wakakora kana mudiki. Murwere akura ane mwongo wemapfupa mashoma uye kazhinji haanyanye kurwadziwa asi kwete nguva dzose. Zvinhu zvinogona kubatsira kuderedza kusagadzikana:
- Paracetamol
- Heat pack
- Loratadine: an over the counter antihistamine, iyo inoderedza mhinduro yekuzvimba
- Bata timu yekurapa kuti ugamuchire analgesia yakasimba kana zviri pamusoro zvikasabatsira
Mhan'ara chero mhedzisiro yakaipa kuchikwata chako chezvehutano.
Rarer side-effect
Vamwe varwere vanogona kuwana spleen yakakura. Udza chiremba kana uine:
- Kunzwa kuzara kana kusagadzikana kuruboshwe rwedumbu, pasi pembabvu
- Marwadzo kuruboshwe rwedumbu
- Marwadzo pamucheto webendekete rekuruboshwe
